Autoantibodies against a 43 KDa Muscle Protein in Inclusion Body MyositisReport as inadecuate




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Background

Inclusion body myositis IBM is a poorly understood and refractory autoimmune muscle disease. Though widely believed to have no significant humoral autoimmunity, we sought to identify novel autoantibodies with high specificity for this disease.

Methodology-Principal Findings

Plasma autoantibodies from 65 people, including 25 with IBM, were analyzed by immunoblots against normal human muscle. Thirteen of 25 52% IBM patient samples recognized an approximately 43 kDa muscle protein. No other disease N = 25 or healthy volunteer N = 15 samples recognized this protein.

Conclusions

Circulating antibodies against a 43-kDa muscle autoantigen may lead to the discovery of a novel biomarker for IBM. Its high specificity for IBM among patients with autoimmune myopathies furthermore suggests a relationship to disease pathogenesis.



Author: Mohammad Salajegheh , Theresa Lam, Steven A. Greenberg

Source: http://plos.srce.hr/



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