Characterization of Changes in Serum Anti-Glycan Antibodies in Crohns Disease – a Longitudinal AnalysisReportar como inadecuado




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Introduction

Anti-glycan antibodies are a promising tool for differential diagnosis and disease stratification of patients with Crohn-s disease CD. We longitudinally assessed level and status changes of anti-glycan antibodies over time in individual CD patients as well as determinants of this phenomenon.

Methods

859 serum samples derived from a cohort of 253 inflammatory bowel disease IBD patients 207 CD, 46 ulcerative colitis UC were tested for the presence of anti-laminarin Anti-L, anti-chitin Anti-C, anti-chitobioside ACCA, anti-laminaribioside ALCA, anti-mannobioside AMCA and anti-Saccharomyces cerevisiae gASCA antibodies by ELISA. All patients had at least two and up to eleven serum samples taken during the disease course.

Results

Median follow-up time for CD was 17.4 months Interquartile range IQR 8.0, 31.6 months and for UC 10.9 months IQR 4.9, 21.0 months. In a subgroup of CD subjects marked changes in the overall immune response quartile sum score and levels of individual markers were observed over time. The marker status positive versus negative remained widely stable. Neither clinical phenotype nor NOD2 genotype was associated with the observed fluctuations. In a longitudinal analysis neither changes in disease activity nor CD behavior led to alterations in the levels of the glycan markers. The ability of the panel to discriminate CD from UC or its association with CD phenotypes remained stable during follow-up. In the serum of UC patients neither significant level nor status changes were observed.

Conclusions

While the levels of anti-glycan antibodies fluctuate in a subgroup of CD patients the antibody status is widely stable over time.



Autor: Florian Rieder , Rocio Lopez, Andre Franke, Alexandra Wolf, Stephan Schleder, Andrea Dirmeier, Anja Schirbel, Philip Rosenstiel,

Fuente: http://plos.srce.hr/



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