Conjunctive Processing of Locomotor Signals by the Ventral Tegmental Area Neuronal PopulationReportar como inadecuado




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The ventral tegmental area VTA plays an essential role in reward and motivation. How the dopamine DA and non-DA neurons in the VTA engage in motivation-based locomotor behaviors is not well understood. We recorded activity of putative DA and non-DA neurons simultaneously in the VTA of awake mice engaged in motivated voluntary movements such as wheel running. Our results revealed that VTA non-DA neurons exhibited significant rhythmic activity that was correlated with the animal-s running rhythms. Activity of putative DA neurons also correlated with the movement behavior, but to a lesser degree. More importantly, putative DA neurons exhibited significant burst activation at both onset and offset of voluntary movements. These findings suggest that VTA DA and non-DA neurons conjunctively process locomotor-related motivational signals that are associated with movement initiation, maintenance and termination.



Autor: Dong V. Wang, Joe Z. Tsien

Fuente: http://plos.srce.hr/



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