Estrogen and Progesterone Receptor Status in Primary Breast Cancer – A Study of 11,273 Patients from the Year 1990 to 2002Reportar como inadecuado




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Collegium antropologicum, Vol.31 No.2 April 2007. -

The aim of this study was to gain insight of the breast cancer hormone receptor status of our patients, its stratification

according to age as well as its changes during the period of 13 years. 11,273 patients with primary breast cancer from

several towns in Croatia were included in this study. Patients’ tumour specimens were collected from 1990 to 2002 and

were analysed on estrogen ER and progesterone PR receptors in the Laboratory of the Department of Medical Oncology,

University Hospital Centre Zagreb. More than half of our breast cancer patients had ER positive tumours 54.3%.

We observed ER+ tumours increased with age continuously, with highest percentage in the age group of 70 to 79 years

68.1%. Similarly, proportion of PR+ tumours was higher in the older age groups, being the highest between 40 and 49

years 55.9%. During 13 years of the study, the increase in frequency and proportion of ER+ tumours was observed

from 52% in 1990 to 62% in 2002 and decrease of PR+ tumours 56% to 53%. We confirm previous findings that the

risk of hormone dependent breast cancer increases with aging. Risk of ER+ breast cancer increased for 10% from 1990 to

2002 and PR+ tumours decreased for 3.5% in the same period.

estrogen receptor; progesterone receptor; breast cancer



Autor: Damir Vrbanec - Branka Petričević -

Fuente: http://hrcak.srce.hr/



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