Ovarian Cancer: PCD and Brain MetastasesReport as inadecuate

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Collegium antropologicum, Vol.31 No.2 April 2007. -

Paraneoplastic cerebellar degeneration PCD, the one of the most common paraneoplastic syndromes, refer to clinical

disorders associated mostly with lung, ovarian and breast cancer, but not directly caused by the cancer or its metastases.

Pathologic finding is an extensive loss of Purkinje cells in the cerebellum. Immunohistocemicaly, the auto-antibodies on

the Purkinje cells had been detected. Clinically, PCD is characterized by sub-acutely evolving pancerebellar symptoms.

Neurological dysfunction may appear before the detection of the underlying cancer. Therefore, the surgical exploration is

necessary for the final diagnosis. The patient undergoes specific therapy. Soon, neurological status of the patient gets irreparable

worse. Death come usually 2–3 years after the first symptoms of the PCD occurs. Case of a 63-years old woman

with PCD as the first evidence of her cancer is reported. The patient developed brain metastases and died almost 3 years

after the first symptoms of PCD occur.

auto-antibodies; brain metastases; gynecologic malignancies; paraneoplastic syndromes

Author: Vesna Stepanić - Višnja Matković - Ante Ćorušić - Dubravko Barišić - Damir Buković - Jadranka Ilić-Forko -

Source: http://hrcak.srce.hr/


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