Vasodilatory Prostaglandins in Perinatal Hypoxic Brain DamageReport as inadecuate

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Collegium antropologicum, Vol.32 - Supplement 1 No.1 May 2008. -

Prostaglandin PGE2 and PGI2 synthesis was determined in the cerebrospinal fluid CSF and serum of 19 hypoxic

neonates at the age of 5–96 hours by using Enzyme Linked Immunosorbent Assay ELISA method. Control group consisted

of 8 children of the same age whose samples were taken due to initial suspicion of neonatal meningitis. The prostaglandin

concentrations in CSF were correlated with initial hypoxic-ischemic encephalopathy HIE stage and neurological

findings of patients at the age of 12 months. The values of PGE2 and PGI2 in the CSF of children with perinatal

hypoxia PNH were significantly higher than in the children from the control group. The values of PGI2 in serum were

significantly higher than in »CSF« of patients with PNH. Although average values of PGE2 and PGI2 in the liquor were

higher in children with advanced stage of HIE, the differences between different stages were not statistically significant.

We did not find any significant correlation between average concentrations of prostaglandins and neurological findings

of the 12-month-old children.

prostaglandins PG; perinatal hypoxia PNH; hypoxic-ischemic encephalopathy HIE; cerebrospinal fluid CSF; neurological outcome

Author: Darinka Šumanović-Glamuzina - Filip Čulo - Melanie-Ivana Čulo - Paško Konjevoda - Tomica Božić - Adisa Robović - Ivana Vu



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