The Role of Endothelin-1 and Nitric Oxide in the Pathogenesis of Hypertension in Diabetic PatientsReportar como inadecuado




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Collegium antropologicum, Vol.32 No.1 May 2008. -

The pathogenesis of renal hypertension has not yet been fully clarified. As the potential role of endothelin-1 ET-1 and

nitric oxide NO has been postulated, their concentrations were determined in plasma and urine of diabetic patients.

The study included 30 diabetic patients both IDDM and NIDDM with initial or advanced diabetic nephropathy decreased

endogenous creatinine clearance, proteinuria and 20 healthy control subjects. The correlation with blood pressure

and other renal function parameters was monitored and compared with the control group. Also, the effect of ACE inhibitors

ACEI on ET-1 and NO patterns was monitored in correlation with arterial hypertension. In diabetic patients

that did not receive ACEI therapy, the increase in plasma ET-1 was associated with both systolic and diastolic blood pressure

elevation, whereas in those administered ACEI the increase in plasma ET-1 was associated with a systolic blood

pressure decline. In addition, the increase in plasma NO was accompanied by a statistically significant decline of both

systolic and diastolic blood pressure in diabetic patients receiving ACEI.

endothelin-1; nitric oxide; diabetes mellitus; hypertension



Autor: Monika Tomić - Krešimir Galešić - Jadranka Morović-Vergles - Željko Romić - Ivanka Mikulić -

Fuente: http://hrcak.srce.hr/



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