The Impact of Obstructive Sleep Apnea on Metabolic and Inflammatory Markers in Consecutive Patients with Metabolic SyndromeReportar como inadecuado




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Background

Obstructive Sleep Apnea OSA is tightly linked to some components of Metabolic Syndrome MetS. However, most of the evidence evaluated individual components of the MetS or patients with a diagnosis of OSA that were referred for sleep studies due to sleep complaints. Therefore, it is not clear whether OSA exacerbates the metabolic abnormalities in a representative sample of patients with MetS.

Methodology-Principal Findings

We studied 152 consecutive patients age 48±9 years, body mass index 32.3±3.4 Kg-m2 newly diagnosed with MetS Adult Treatment Panel III. All participants underwent standard polysomnography irrespective of sleep complaints, and laboratory measurements glucose, lipid profile, uric acid and C-reactive protein. The prevalence of OSA apnea-hypopnea index ≥15 events per hour of sleep was 60.5%. Patients with OSA exhibited significantly higher levels of blood pressure, glucose, triglycerides, cholesterol, LDL, cholesterol-HDL ratio, triglycerides-HDL ratio, uric acid and C-reactive protein than patients without OSA. OSA was independently associated with 2 MetS criteria: triglycerides: OR: 3.26 1.47–7.21 and glucose: OR: 2.31 1.12–4.80. OSA was also independently associated with increased cholesterol-HDL ratio: OR: 2.38 1.08–5.24, uric acid: OR: 4.19 1.70–10.35 and C-reactive protein: OR: 6.10 2.64–14.11. Indices of sleep apnea severity, apnea-hypopnea index and minimum oxygen saturation, were independently associated with increased levels of triglycerides, glucose as well as cholesterol-HDL ratio, uric acid and C-reactive protein. Excessive daytime sleepiness had no effect on the metabolic and inflammatory parameters.

Conclusions-Significance

Unrecognized OSA is common in consecutive patients with MetS. OSA may contribute to metabolic dysregulation and systemic inflammation in patients with MetS, regardless of symptoms of daytime sleepiness.



Autor: Luciano F. Drager , Heno F. Lopes, Cristiane Maki-Nunes, Ivani C. Trombetta, Edgar Toschi-Dias, Maria Janieire N. N. Alves, Raffa

Fuente: http://plos.srce.hr/



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