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Acta Pharmaceutica, Vol.58 No.2 June 2008. -

Gastro retentive controlled release system of loratadine was formulated to increase the residence time in stomach and to modulate the release behaviour of the drug. Oil entrapped floating microbeads prepared by emulsion gelation method were optimized by 23 factorial design and a polymer ratio of 2.5:1.5 pectin: sodium alginate by mass, 15% m-v of oil mineral oil or castor oil and 0.45 mol L-1 calcium chloride solution were selected as the optimized processing conditions for the desired buoyancy and physical stability. In vitro drug release in fed state conditions demonstrated sustained release of loratadine for 8 h that best fitted the Peppas model with n < 0.45. The ethylcellulose coating on microbeads optimized by 22 factorial design resulted in controlled release formulation of loratadine that provided zero-order release for 8 h.

loratadine; gastroretentive; factorial design; ethylcellulose coating; zero-order release



Autor: SHASHI KIRAN MISHRA - ; 1Advanced Institute of Biotechnology and Paramedical Sciences, Kanpur, India KAMLA PATHAK - ; Department

Fuente: http://hrcak.srce.hr/



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