Seasonal Influenza Vaccine and Protection against Pandemic H1N1 2009-Associated Illness among US Military PersonnelReportar como inadecuado

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A novel A-H1N1 virus is the cause of the present influenza pandemic; vaccination is a key countermeasure, however, few data assessing prior seasonal vaccine effectiveness VE against the pandemic strain of H1N1 pH1N1 virus are available.

Materials and Methods

Surveillance of influenza-related medical encounter data of active duty military service members stationed in the United States during the period of April–October 2009 with comparison of pH1N1-confirmed cases and location and date-matched controls. Crude odds ratios OR and VE estimates for immunized versus non-immunized were calculated as well as adjusted OR AOR controlling for sex, age group, and history of prior influenza vaccination. Separate stratified VE analyses by vaccine type trivalent inactivated TIV or live attenuated LAIV, age groups and hospitalization status were also performed. For the period of April 20 to October 15, 2009, a total of 1,205 cases of pH1N1-confirmed cases were reported, 966 80% among males and over one-half 58% under 25 years of age. Overall VE for service members was found to be 45% 95% CI, 33 to 55%. Immunization with prior season-s TIV VE = 44%, 95% CI, 32 to 54% as well as LAIV VE = 24%, 95% CI, 6 to 38% were both found to be associated with protection. Of significance, VE against a severe disease outcome was higher VE = 62%, 95% CI, 14 to 84% than against milder outcomes VE = 42%, 95% CI, 29 to 53%.


A moderate association with protection against clinically apparent, laboratory-confirmed Pandemic H1N1 2009-associated illness was found for immunization with either TIV or LAIV 2008–09 seasonal influenza vaccines. This association with protection was found to be especially apparent for severe disease as compared to milder outcome, as well as in the youngest and older populations. Prior vaccination with seasonal influenza vaccines in 2004–08 was also independently associated with protection.

Autor: Matthew C. Johns , Angelia A. Eick, David L. Blazes, Seung-eun Lee, Christopher L. Perdue, Robert Lipnick, Kelly G. Vest, Kevin L



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