Etodolac Attenuates Hippocampal Blood Flow Responses Induced by Tooth Pulp Stimulation in RatsReportar como inadecuado




Etodolac Attenuates Hippocampal Blood Flow Responses Induced by Tooth Pulp Stimulation in Rats - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

In this study, we investigated whether increases in hippocampal blood flow HBF by tooth pulp stimulation TPS are mediated via the activation of cyclooxygenase-2 COX-2. We measured mean arterial blood pressure MABP and HBF in urethane-anesthetized rats using laser Doppler flowmetry and examined the effects of etodolac, a specific COX-2 inhibitor, on TPS-induced MABP and HBF responses. The MABP response was not attenuated by the intraperitoneal i.p. administration of etodolac 10 mg-kg; however, the HBF response was significantly attenuated by etodolac administration. These results suggest that COX-2 may be involved in the mechanisms regulating TPS-induced HBF responses.

KEYWORDS

Cyclooxygenase-2 COX-2, Etodolac, Fear Memory, Hippocampal Blood Flow, Mean Arterial Blood Pressure, Tooth Pulp Stimulation

Cite this paper

M. Hasegawa, J. Hada, T. Abe, N. Ohtsu, K. Honda and M. Urade -Etodolac Attenuates Hippocampal Blood Flow Responses Induced by Tooth Pulp Stimulation in Rats,- Neuroscience and Medicine, Vol. 2 No. 3, 2011, pp. 295-298. doi: 10.4236-nm.2011.23038.





Autor: Makoto Hasegawa, Junichi Hada, Tetsuya Abe, Nao Ohtsu, Kousuke Honda, Masahiro Urade

Fuente: http://www.scirp.org/



DESCARGAR PDF




Documentos relacionados