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Acta Pharmaceutica, Vol.55 No.4 December 2005. -

Antifungal activities of fluid extract and essential oil obtained from anise fruits Pimpinella anisum L. Apiaceae were tested in vitro on clinical isolates of seven species of yeasts and four species of dermatophytes. Diffusion method with cylinders and the broth dilution method were used for antifungal activity testing. Anise fluid extract showed antimycotic activity against Candida albicans, C. parapsilosis, C. tropicalis, C. pseudotropicalis and C. krusei with MIC values between 17 and 20% V-V. No activity was noticed against C. glabrata, and anis fruits extracts showed growth promotion activity on Geotrichum spp. Anise fruits extract inhibited the growth of dermatophyte species Trichophyton rubrum, T. mentagrophytes, Microsporum canis and M. gypseum with MIC values between 1.5 and 9% V-V. Anise essential oil showed strong antifungal activity against yeasts with MIC lower than 1.56% V-V and dermatophytes with MIC lower than 0.78% V-V. Significant differences in antifungal activities were found between anise fluid extract and anise essential oil p < 0.01. Anise essential oil exhibited stronger antifungal activities against yeasts and dermatophytes with MIC values between 0.10 and 1.56% V-V, respectively.

anise; anise fruits; Pimpinella anisum Apiaceae; fluid extract; essential oil; antifungal activity; Candida; dermatophyte



Autor: IVAN KOSALEC - STJEPAN PEPELJNJAK - DANICA KUŠTRAK -

Fuente: http://hrcak.srce.hr/



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