The Relationship between Hyperhomocysteinemia, Haemostatic Factors and Acute Coronary Syndrome in Southeastern Turkey: A Prospective, Comparative StudyReportar como inadecuado




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Aim: We investigated the relationship between hyperhomocysteinemia, coagulation factors and acute coronary syndrome. Materials and method: The study was conducted at cardiology and hematology department of Dicle University Medical School between January 1st 2003 and May 31st 2009. The study included 96 patients with acute coronary syn-drome and 96 controls. Results: Baseline characteristics of patients 63 males, 33 females, mean age 56.4 years and controls 58 males and 38 females, mean age: 51.1 years were similar. There was a statistically significant difference between two groups according to homocysteine levels 13.4 ±8.0 micromole-L vs. 12.8 ± 7.1 micromole-L p = 0.042. In this study, we found that hyperhomocysteinemia, smoking, elevated levels of CRP, low levels of HDL, positive family history, presence of hypertension, BMI > 27, low levels of protein C and protein S were associated with high risk for acute coronary syndrome. Fibrinogen level, factor V level, factor VIII level, factor IX level ,factor X level ,and factor V leiden p = 0.128 are not risk factors for acute coronary syndrome. Conclusion: Hyperhomocysteine is a significant risk factor for acute coronary syndrome There is not relationship between coagulation factors and acute coronary syn-drome except low levels of protein C and protein S.

KEYWORDS

hyperhomocysteinemia, coagulation factors, Acute Coronary Syndrome

Cite this paper

M. Yakut, O. Ayyıldız, S. Batum and S. Alan -The Relationship between Hyperhomocysteinemia, Haemostatic Factors and Acute Coronary Syndrome in Southeastern Turkey: A Prospective, Comparative Study,- International Journal of Clinical Medicine, Vol. 2 No. 3, 2011, pp. 272-277. doi: 10.4236-ijcm.2011.23044.





Autor: Mustafa Yakut, Orhan Ayyıldız, Sabri Batum, Sait Alan

Fuente: http://www.scirp.org/



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