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Type 2 diabetes T2D is a metabolic disorder characterized by disturbances of carbohydrate, fat and protein metabolism and insulin resistance. The majority of T2D patients are obese and obesity by itself may be a cause of insulin resistance. Our aim was to evaluate whether the recently identified T2D risk alleles are associated with human measures of fatness as characterized with Dual Energy X-ray Absorptiometry DEXA.

Methodology-Principal Findings

Genotypes and phenotypes of approximately 3,000 participants from cross-sectional ERF study were analyzed. Nine single nucleotide polymorphisms SNPs in CDKN2AB, CDKAL1, FTO, HHEX, IGF2BP2, KCNJ11, PPARG, SLC30A8 and TCF7L2 were genotyped. We used linear regression to study association between individual SNPs and the combined allelic risk score with body mass index BMI, fat mass index FMI, fat percentage FAT, waist circumference WC and waist to hip ratio WHR. Significant association was observed between rs8050136 FTO and BMI p = 0.003, FMI p = 0.007 and WC p = 0.03; fat percentage was borderline significant p = 0.053. No other SNPs alone or combined in a risk score demonstrated significant association to the measures of fatness.


From the recently identified T2D risk variants only the risk variant of the FTO gene rs8050136 showed statistically significant association with BMI, FMI, and WC.

Autor: Slavica Pecioska, M. Carola Zillikens, Peter Henneman, Pieter J. Snijders, Ben A. Oostra, Cornelia M. van Duijn, Yurii S. Aulchen



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