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Background: Depression is often viewed as a risk factor for the development of Alzheimer-s disease AD, however little is known regarding the underlying biological mechanisms linking these two diseases. Brain-derived neurotrophic factor BDNF has been linked to both cognitive impairment and depression in past research; however few studies have ex-amined this relation in a sample of Alzheimer-s patients. The present study sought to address this gap in the literature by examining the relation between serum BDNF levels and depression assessed by the Geriatric Depression Scale GDS in a group of patients diagnosed with probable Alzheimer-s disease. Methods: Participants included 169 individuals diagnosed with Probable AD enrolled in the TARC Longitudinal Research Cohort with available BDNF levels and GDS scores. The participants were divided into Depressed N = 20 and Not Depressed N = 149 based on GDS scores. Re-sults: BDNF levels significantly predicted level High vs. Low of depression β = 0.066, SE = 0.031, p = 0.034. BDNF levels for the Depressed group were significantly higher than those observed in the Not Depressed group p. > 0.036. Conclusions: These findings suggest that an upregulation of BDNF possibly exists among depressed AD patients as a response to the chronic inflammatory processes that occur in depression. This upregulation of BDNF appears to persist at least into early stages of Alzheimer-s.

KEYWORDS

Alzheimer-s Disease, Depression, BDNF, Depression Severity

Cite this paper

J. Hall, S. O-Bryant, L. Johnson and R. Barber -Depression and Brain-derived Neurotrophic Factor Levels in Alzheimer-s Disease,- Neuroscience and Medicine, Vol. 2 No. 1, 2011, pp. 43-47. doi: 10.4236-nm.2011.21006.





Autor: James R. Hall, Sid E. O-Bryant, Leigh Johnson, Robert C. Barber

Fuente: http://www.scirp.org/



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