rTMS of the Left Dorsolateral Prefrontal Cortex Modulates Dopamine Release in the Ipsilateral Anterior Cingulate Cortex and Orbitofrontal CortexReportar como inadecuado




rTMS of the Left Dorsolateral Prefrontal Cortex Modulates Dopamine Release in the Ipsilateral Anterior Cingulate Cortex and Orbitofrontal Cortex - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Background

Brain dopamine is implicated in the regulation of movement, attention, reward and learning and plays an important role in Parkinson-s disease, schizophrenia and drug addiction. Animal experiments have demonstrated that brain stimulation is able to induce significant dopaminergic changes in extrastriatal areas. Given the up-growing interest of non-invasive brain stimulation as potential tool for treatment of neurological and psychiatric disorders, it would be critical to investigate dopaminergic functional interactions in the prefrontal cortex and more in particular the effect of dorsolateral prefrontal cortex DLPFC areas 9-46 stimulation on prefrontal dopamine DA.

Methodology-Principal Findings

Healthy volunteers were studied with a high-affinity DA D2-receptor radioligand, 11CFLB 457-PET following 10 Hz repetitive transcranial magnetic stimulation rTMS of the left and right DLPFC. rTMS on the left DLPFC induced a significant reduction in 11CFLB 457 binding potential BP in the ipsilateral subgenual anterior cingulate cortex ACC BA 25-12, pregenual ACC BA 32 and medial orbitofrontal cortex BA 11. There were no significant changes in 11CFLB 457 BP following right DLPFC rTMS.

Conclusions-Significance

To our knowledge, this is the first study to provide evidence of extrastriatal DA modulation following acute rTMS of DLPFC with its effect limited to the specific areas of medial prefrontal cortex. 11CFLB 457-PET combined with rTMS may allow to explore the neurochemical functions of specific cortical neural networks and help to identify the neurobiological effects of TMS for the treatment of different neurological and psychiatric diseases.



Autor: Sang Soo Cho, Antonio P. Strafella

Fuente: http://plos.srce.hr/



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