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Purpose: To investigate dynamic changes and significance of lymphocyte subsets T lymphocytes, B lymphocytes, NK cells and T cell subsets of peripheral blood in patients with acute self-limited hepatitis B AHB. Methods: Immune cells of peripheral blood were compared among 17 cases of self-limited acute hepatitis B patients, 36 patients with chronic hepatitis B CHB and 32 healthy controls by flow cytometry FCM. CD4+-CD8+ was monitored dynamically, meanwhile relations between T lymphocyte subsets and ALT and clearance of HBV DNA were explored. Results: Dynamic changes of lymphocyte subsets were found in AHB, the level of CD3+T cells was significantly higher compared to CHB group and healthy control group. Frequencies of CD3+CD4+ T cells in the third and fourth week and CD4+-CD8+ in the second week were higher compared to other groups. Frequ- ency of NK cells was low and was significantly lower compared to other groups in the third week specially. It was showed that CD4+-CD8+ was low followed by high abnormal ALT during early stage by dynamic monitoring of CD4+-CD8+, and CD4+-CD8+ was increasing accompanied by normal ALT set by set, but CD4+-CD8+ had no significant relation to ALT and HBV DNA. Conclusion: Immune status of AHB, compared to CHB and healthy controls, was significantly different and dynamic changes of lymphocyte sub- sets may be related to progress of disease.

KEYWORDS

Acute Hbv; Self-Limited; Lymphocyte Subsets; Facs

Cite this paper

Liu, B. , Li, J. , Han, Y. , Liu, Y. , Kong, L. , Cao, Y. and Huang, Z. 2010 Dynamic analysis of lymphocyte subsets of peripheral blood in patients with acute self-limited hepatitis B. Health, 2, 736-741. doi: 10.4236-health.2010.27112.





Autor: Bo Liu, Jun Li, Yaping Han, Yuan Liu, Lianhua Kong, Yang Cao, Zuhu Huang

Fuente: http://www.scirp.org/



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