Influence of poloxamer 407 on fractional and subfractional composition of serum lipoproteins of miceReportar como inadecuado




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Using a novel small-angle X-ray scattering SAXS method for determination of fractional and subfractional composition of lipoproteins LPs, a significant elevation of total cholesterol-lipop- roteins C-LP and, especially, total triglyceride- lipoproteins TG-LP, was shown in this work. Among the LP fractions, poloxamer 407 was shown to significantly increase proatherogenic total C-LDL, TG-LDL and, especially, their precursors C-VLDL and TG-VLDL, while only exhibiting a moderate increase in the antiatherogenic C-HDL and TG-HDL fractions. With regard to the VLDL subfractions, significant elevations were observed in both subfractions studied; namely, C-VLDL1-2 and C-VLDL3-5. Similar chang- es were noted in the TG-VLDL1-2 and TG- VLDL3-5 subfractions. The C-IDL and TG-IDL subfractions were increased significantly ?20- to 30- fold, while the C-LDL1-3 subfraction was moderately ?3- to 5-fold increased at 48 hrs and at day 4. In the moderately elevated ?2- to 4-fold anti-atherogenic HDL fraction, the C-HDL2 subfraction was increased more significantly ?4- fold compared to the C-HDL3 subfraction; how- ever, both C-HDL subfractions returned to base- line by day 4. The elevation in the TG-HDL2 subfraction was observed only at 24 hrs. Mouse models of hyperlipidemia and atherosclerosis are useful to evaluate the role of -individual- LPs, as well as their fractions and subfractions, in hyperlipidemia and the genesis of atherosclerosis.

KEYWORDS

Poloxamer P-407; Dyslipidemia; Serum Lipoprotein Fractions and Subfractions

Cite this paper

Korolenko, T. , Tuzikov, F. , Johnston, T. , Tuzikova, N. , Filjushina, E. , Loginova, V. and Savchenko, N. 2010 Influence of poloxamer 407 on fractional and subfractional composition of serum lipoproteins of mice. Health, 2, 722-730. doi: 10.4236-health.2010.27110.





Autor: Tatyana A. Korolenko, Fedor V. Tuzikov, Thomas P. Johnston, Natalia A. Tuzikova, Elena E. Filjushina, Viktoriya M. Loginova, Nata

Fuente: http://www.scirp.org/



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