Impact of Inflammatory Cell Activation on Nasal Hyperreactive Response to Distilled Water Nasal ProvocationReportar como inadecuado




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Acta clinica Croatica, Vol.46 No.2 June 2007. -

The aim of the study was to compare hyperreactive response to nasal distilled water provocation in patients with allergic and non-allergic hyperreactive rhinitis, and to correlate the severity of hyperreactivity with inflammatory cell activation. Cellular activity was measured by the concentration of cellular activation markers in nasal lavage prior to provocation, eosinophil cationic protein ECP for eosinophil granulocytes, myeloperoxidase MPO for neutrophilic granulocytes and tryptase for mast cells. The study was performed in a group of 78 patients with a history of nasal hyperreactivity, i.e. 48 patients with allergic rhinitis and 30 patients with non-infectious non-allergic rhinitis NINAR. Prior to provocation, basal nasal airway resistance was measured by active anterior rhinomanometry, and nasal lavage with 5 ccm of saline was taken. Provocation was made by inhalation of 10 ccm of distilled water over 10 minutes. The patients were subdivided into groups according to nasal airway resistance NAR increase. In the whole group the provocation induced a significant increase in nasal resistance on the better patent side prior to provocation p



Autor: Krešo Zurak - Željka Bukovec - Srđan Ante Anzic - Tomislav Baudoin - Livije Kalogjera -

Fuente: http://hrcak.srce.hr/



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