HIV Induces TRAIL Sensitivity in HepatocytesReportar como inadecuado




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Background

HIV infected patients have an increased susceptibility to liver disease due to Hepatitis B Virus HBV, Hepatitis C Virus HCV, alcoholic, and non-alcoholic steatohepatitis. Clinically, this results in limited options for antiretroviral therapy and accelerated rates of liver disease, causing liver disease to be the second leading cause of death for HIV infected patients. The mechanisms causing this propensity for liver dysfunction during HIV remains unknown.

Methodology-Principal Findings

We demonstrate that HIV and-or the HIV glycoprotein gp120 ligation of CXCR4 on hepatocytes selectively up-regulates TRAIL R2 expression and confers an acquired sensitivity to TRAIL mediated apoptosis which is mediated by JNK II, but not p38 nor G-proteins.

Conclusions-Significance

These findings suggest that HIV infection renders hepatocytes more susceptible to liver injury during disease states associated with enhanced TRAIL production such as HBV, HCV, or steatohepatitis.



Autor: Challagundla K. Babu, Kanitta Suwansrinon, Gary D. Bren, Andrew D. Badley, Stacey A. Rizza

Fuente: http://plos.srce.hr/



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