Identification and Characterization of a New Orthoreovirus from Patients with Acute Respiratory InfectionsReportar como inadecuado

Identification and Characterization of a New Orthoreovirus from Patients with Acute Respiratory Infections - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

First discovered in the early 1950s, reoviruses respiratory enteric orphan viruses were not associated with any known disease, and hence named orphan viruses. Recently, our group reported the isolation of the Melaka virus from a patient with acute respiratory disease and provided data suggesting that this new orthoreovirus is capable of human-to-human transmission and is probably of bat origin. Here we report yet another Melaka-like reovirus named Kampar virus isolated from the throat swab of a 54 year old male patient in Kampar, Perak, Malaysia who was suffering from high fever, acute respiratory disease and vomiting at the time of virus isolation. Serological studies indicated that Kampar virus was transmitted from the index case to at least one other individual and caused respiratory disease in the contact case. Sequence analysis of the four small class genome segments indicated that Kampar and Melaka viruses are closely related. This was confirmed by virus neutralization assay, showing an effective two-way cross neutralization, i.e., the serum against one virus was able to neutralize the other. Although the exact origin of Kampar virus is unknown, epidemiological tracing revealed that the house of the index case is surrounded by fruit trees frequently visited by fruit bats. There is a high probability that Kampar virus originated from bats and was transmitted to humans via bat droppings or contaminated fruits. The discovery of Kampar virus highlights the increasing trend of emergence of bat zoonotic viruses and the need to expand our understanding of bats as a source of many unknown viruses.

Autor: Kaw Bing Chua , Kenny Voon, Gary Crameri, Hui Siu Tan, Juliana Rosli, Jennifer A. McEachern, Sivagami Suluraju, Meng Yu, Lin-Fa W



Documentos relacionados