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Collegium antropologicum, Vol.24 No.2 December 2000. -

The HLA class I polymorphism was studied in a sample of the Albanian population. Ninety-three unrelated healthy Albanians were typed for HLA-A -B and -Cw antigens by standard microlyphocytotoxicity test. The antigens with the highest frequencies were:

HLA-A2 34.4%, A3 14.5% and A1 12.4%; B51 19.3%, B35 12.4% and B18 10.2%; Cw4 16.2%, Cw7 16.2% and Cw6 10.8%. The HLA haplotypes with high frequency in Albanians included A2-B51 4.3%, A2-B18 2.4%, A2-B35 2.4%, Cw4-B35 7.6%, and Cw7-B18 6.5%, which are not significantly different from the other neighboring populations. Low frequency of HLA-A1-B8 haplotype 1.1% is noted in the Albanian population. The frequency of HLA-B27 antigen 1.1% is one of the lowest frequencies observed in Caucasians. Such results are important in studies of HLA-A1-B8, HLA-B27 and disease associations. These findings should be also useful in understanding the origin of Albanians, representing a base for future studies about HLA polymorphism in the Albanian population.



Autor: Z. Grubić - V. Kerhin-Brkljačić - E. Čečuk-Jeličić - S. Kuci - A. Kaštelan -

Fuente: http://hrcak.srce.hr/



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