The Plasmodium Export Element RevisitedReportar como inadecuado

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We performed a bioinformatical analysis of protein export elements PEXEL in the putative proteome of the malaria parasite Plasmodium falciparum. A protein family-specific conservation of physicochemical residue profiles was found for PEXEL-flanking sequence regions. We demonstrate that the family members can be clustered based on the flanking regions only and display characteristic hydrophobicity patterns. This raises the possibility that the flanking regions may contain additional information for a family-specific role of PEXEL. We further show that signal peptide cleavage results in a positional alignment of PEXEL from both proteins with, and without, a signal peptide.

Autor: Jan Alexander Hiss , Jude Marek Przyborski, Florian Schwarte, Klaus Lingelbach, Gisbert Schneider



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