Molecular Pathogenesis and Therapy of Polycythemia Induced in Mice by JAK2 V617FReportar como inadecuado




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AbstractBackgroundA somatic activating mutation (V617F) in the JAK2 tyrosine kinase was recently discovered in the majority of patients with polycythemia vera (PV), and some with essential thrombocythemia (ET) and chronic idiopathic myelofibrosis. However, the role of mutant JAK2 in disease pathogenesis is unclear.



Autor: Virginia M. Zaleskas, Daniela S. Krause, Katherine Lazarides, Nihal Patel, Yiguo Hu, Shaoguang Li, Richard A. Van Etten

Fuente: http://plos.srce.hr/



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