Deletion-Deletion Genotype of Angiotensin-I Converting Enzyme Gene is not Associated with Coronary Artery Disease in Caucasians with Type 2 DiabetesReportar como inadecuado




Deletion-Deletion Genotype of Angiotensin-I Converting Enzyme Gene is not Associated with Coronary Artery Disease in Caucasians with Type 2 Diabetes - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Collegium antropologicum, Vol.29 No.1 June 2005. -

In this study we analyzed the contribution of genetic variability of the insertion-deletion (I-D) polymorphism of the angiotensin-I converting enzyme (ACE) gene to the predisposition for coronary artery disease (CAD) in a group of patients with type 2 diabetes. The I-D ACE gene polymorphism was tested in 366 Caucasians with type 2 diabetes: 148 cases with CAD and 218 subjects with no history of CAD. We failed to demonstrate that the ACE DD genotype was a risk factor for CAD in Caucasians with type 2 diabetes (OR 2.0, 95 % CI 0.9–4.7; p=0.1). In conclusion, we provide evidence that the ACE deletion-deletion genotype is not a risk factor for CAD in Caucasians with type 2 diabetes.

angiotensin-I converting enzyme; coronary artery disease; diabetes type 2



Autor: Ruda Zorc-Pleskovič - Nataša Teran - Aleš Pleskovič - Rifet Terzić - Aleksandra Milutinović -

Fuente: http://hrcak.srce.hr/



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