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Abstract: The conformational behavior of a giant DNA mediated by condensing agents inthe bulk solution has been investigated through experimental and theoreticalapproaches. Experimentally, a pronounced conformational hysteresis is observedfor folding and unfolding processes, by increasing and decreasing theconcentration of condensing agent PEG (Polyethylene glycol), respectively. Toelucidate the observed hysteresis, a semiflexible chain model is studied byusing Monte Carlo simulations for the coil-globule transition. In thesimulations, the hysteresis loop emerges for stiff enough chains, indicatingdistinct pathways for folding and unfolding processes. Also, our results showthat globular state is thermodynamically more stable than coiled state in thehysteresis loop. Our findings suggest that increasing chain stiffness mayreduce the chain conformations relevant to the folding pathway, which impedesthe folding process.



Autor: Chwen-Yang Shew, Yuji Higuchi, Kenichi Yoshikawa

Fuente: https://arxiv.org/







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