Playing Hide and Seek: How Glycosylation of the Influenza Virus Hemagglutinin Can Modulate the Immune Response to InfectionReportar como inadecuado




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1

Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, 3168, Australia

2

Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria 3010, Australia

3

WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, at the Peter Doherty Institute for Infection and Immunity, Victoria 3010, Australia

4

Bioinformatics Institute, Agency for Science, Technology and Research, 138671, Singapore

5

School of Biological Sciences, Nanyang Technological University, 639798, Singapore

6

National Public Health Laboratory, Communicable Diseases Division, Ministry of Health, 169854, Singapore





*

Author to whom correspondence should be addressed.



Abstract Seasonal influenza A viruses IAV originate from pandemic IAV and have undergone changes in antigenic structure, including addition of glycans to the hemagglutinin HA glycoprotein. The viral HA is the major target recognized by neutralizing antibodies and glycans have been proposed to shield antigenic sites on HA, thereby promoting virus survival in the face of widespread vaccination and-or infection. However, addition of glycans can also interfere with the receptor binding properties of HA and this must be compensated for by additional mutations, creating a fitness barrier to accumulation of glycosylation sites. In addition, glycans on HA are also recognized by phylogenetically ancient lectins of the innate immune system and the benefit provided by evasion of humoral immunity is balanced by attenuation of infection. Therefore, a fine balance must exist regarding the optimal pattern of HA glycosylation to offset competing pressures associated with recognition by innate defenses, evasion of humoral immunity and maintenance of virus fitness. In this review, we examine HA glycosylation patterns of IAV associated with pandemic and seasonal influenza and discuss recent advancements in our understanding of interactions between IAV glycans and components of innate and adaptive immunity. View Full-Text

Keywords: influenza virus; glycosylation; immune evasion; lectin influenza virus; glycosylation; immune evasion; lectin





Autor: Michelle D. Tate 1, Emma R. Job 2, Yi-Mo Deng 3, Vithiagaran Gunalan 4, Sebastian Maurer-Stroh 4,5,6 and Patrick C. Reading 2,3,*

Fuente: http://mdpi.com/



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