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1

Department of Biochemistry, University of Wuerzburg, Wuerzburg D-97074, Germany

2

Genelux Corporation, San Diego Science Center, San Diego, CA 92109, USA

3

Department of Radiation Medicine and Applied Sciences, Rebecca and John Moores Comprehensive Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA





*

Authors to whom correspondence should be addressed.



Abstract Cancer is the leading cause of disease-related death in companion animals such as dogs and cats. Despite recent progress in the diagnosis and treatment of advanced canine and feline cancer, overall patient treatment outcome has not been substantially improved. Virotherapy using oncolytic viruses is one promising new strategy for cancer therapy. Oncolytic viruses OVs preferentially infect and lyse cancer cells, without causing excessive damage to surrounding healthy tissue, and initiate tumor-specific immunity. The current review describes the use of different oncolytic viruses for cancer therapy and their application to canine and feline cancer. View Full-Text

Keywords: cancer; canine and feline cancer therapy; oncolytic virus; oncolysis cancer; canine and feline cancer therapy; oncolytic virus; oncolysis





Autor: Ivaylo Gentschev 1,2,* , Sandeep S. Patil 1, Ivan Petrov 1, Joseph Cappello 2, Marion Adelfinger 1 and Aladar A. Szalay 1,2,3,*

Fuente: http://mdpi.com/



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