The DNA Damage Response Induced by Infection with Human Cytomegalovirus and Other VirusesReportar como inadecuado




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1

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA 01605, USA

2

Program in Immunology and Microbiology, University of Massachusetts Medical School, 368 Plantation St, Worcester, MA 01605, USA





*

Author to whom correspondence should be addressed.



Abstract Viruses use different strategies to overcome the host defense system. Recent studies have shown that viruses can induce DNA damage response DDR. Many of these viruses use DDR signaling to benefit their replication, while other viruses block or inactivate DDR signaling. This review focuses on the effects of DDR and DNA repair on human cytomegalovirus HCMV replication. Here, we review the DDR induced by HCMV infection and its similarities and differences to DDR induced by other viruses. As DDR signaling pathways are critical for the replication of many viruses, blocking these pathways may represent novel therapeutic opportunities for the treatment of certain infectious diseases. Lastly, future perspectives in the field are discussed. View Full-Text

Keywords: HCMV; cell cycle; DNA damage response; DDR; ATM HCMV; cell cycle; DNA damage response; DDR; ATM





Autor: Xiaofei E 1,2 and Timothy F. Kowalik 1,2,*

Fuente: http://mdpi.com/



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