Chloroviruses Have a Sweet ToothReportar como inadecuado


Chloroviruses Have a Sweet Tooth


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1

Department of Plant Pathology and Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583-0900, USA

2

Department of Experimental Medicine and Center of Excellence for Biomedical Research, University of Genova Viale Benedetto XV-1, 16132 Genova, Italy

3

Department of Agricultural Sciences, University of Napoli, Via Università 100, 80055 Portici, NA, Italy

4

Department of Biology, Nebraska Wesleyan University, Lincoln, NE 68504-2796, USA





*

Author to whom correspondence should be addressed.



Abstract Chloroviruses are large double-stranded DNA dsDNA viruses that infect certain isolates of chlorella-like green algae. They contain up to approximately 400 protein-encoding genes and 16 transfer RNA tRNA genes. This review summarizes the unexpected finding that many of the chlorovirus genes encode proteins involved in manipulating carbohydrates. These include enzymes involved in making extracellular polysaccharides, such as hyaluronan and chitin, enzymes that make nucleotide sugars, such as GDP-L-fucose and GDP-D-rhamnose and enzymes involved in the synthesis of glycans attached to the virus major capsid proteins. This latter process differs from that of all other glycoprotein containing viruses that traditionally use the host endoplasmic reticulum and Golgi machinery to synthesize and transfer the glycans. View Full-Text

Keywords: chloroviruses; giant viruses; hyaluronan synthesis; chitin synthesis; nucleotide sugar synthesis; glycan synthesis; glycan structures; glycoproteins chloroviruses; giant viruses; hyaluronan synthesis; chitin synthesis; nucleotide sugar synthesis; glycan synthesis; glycan structures; glycoproteins





Autor: James L. Van Etten 1,* , Irina Agarkova 1, David D. Dunigan 1, Michela Tonetti 2, Christina De Castro 3 and Garry A. Duncan 4

Fuente: http://mdpi.com/



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