Interplay between the Hepatitis B Virus and Innate Immunity: From an Understanding to the Development of Therapeutic ConceptsReportar como inadecuado


Interplay between the Hepatitis B Virus and Innate Immunity: From an Understanding to the Development of Therapeutic Concepts


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Cancer Research Center of Lyon CRCL, INSERM, U1052, CNRS, University of Lyon, UMR-5286, 69003 Lyon, France





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Academic Editors: Ulrike Protzer and Michael Nassal

Abstract The hepatitis B virus HBV infects hepatocytes, which are the main cell type composing a human liver. However, the liver is enriched with immune cells, particularly innate cells e.g., myeloid cells, natural killer and natural killer T-cells NK-NKT, dendritic cells DCs, in resting condition. Hence, the study of the interaction between HBV and innate immune cells is instrumental to: 1 better understand the conditions of establishment and maintenance of HBV infections in this secondary lymphoid organ; 2 define the role of these innate immune cells in treatment failure and pathogenesis; and 3 design novel immune-therapeutic concepts based on the activation-restoration of innate cell functions and-or innate effectors. This review will summarize and discuss the current knowledge we have on this interplay between HBV and liver innate immunity. View Full-Text

Keywords: HBV; liver immunity; innate immunity; viral escape; immune therapeutic concepts HBV; liver immunity; innate immunity; viral escape; immune therapeutic concepts





Autor: Suzanne Faure-Dupuy, Julie Lucifora and David Durantel *

Fuente: http://mdpi.com/



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