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Redistribution of Endosomal Membranes to the African Swine Fever Virus Replication Site


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1

Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, INIA, Ctra. de la Coruña Km 7.5, 28040 Madrid, Spain

2

Department of Infectious Diseases, King’s College London School of Medicine, Guy’s Hospital, London SE1 9RT, UK

3

Department of Microbiology and Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA





*

Author to whom correspondence should be addressed.



Abstract African swine fever virus ASFV infection causes endosomal reorganization. Here, we show that the virus causes endosomal congregation close to the nucleus as the infection progresses, which is necessary to build a compact viral replication organelle. ASFV enters the cell by the endosomal pathway and reaches multivesicular late endosomes. Upon uncoating and fusion, the virus should exit to the cytosol to start replication. ASFV remodels endosomal traffic and redistributes endosomal membranes to the viral replication site. Virus replication also depends on endosomal membrane phosphoinositides PtdIns synthesized by PIKfyve. Endosomes could act as platforms providing membranes and PtdIns, necessary for ASFV replication. Our study has revealed that ASFV reorganizes endosome dynamics, in order to ensure a productive infection. View Full-Text

Keywords: african swine fever virus ASFV; ASF viral factory; endosomes; endosomal pathway; phosphoinositides; phosphatidylinositol kinases; microtubules african swine fever virus ASFV; ASF viral factory; endosomes; endosomal pathway; phosphoinositides; phosphatidylinositol kinases; microtubules





Autor: Miguel Ángel Cuesta-Geijo 1,2, Lucía Barrado-Gil 1, Inmaculada Galindo 1, Raquel Muñoz-Moreno 3 and Covadonga Alonso 1,*

Fuente: http://mdpi.com/



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