Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome VirusReportar como inadecuado


Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome Virus


Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome Virus - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Department of Veterinary and Biomedical Sciences, University of Minnesota, 1971 Commonwealth Avenue, St. Paul, MN 55108, USA





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Academic Editors: Linda Dixon and Simon Graham

Abstract The adaptive immune response is necessary for the development of protective immunity against infectious diseases. Porcine reproductive and respiratory syndrome virus PRRSV, a genetically heterogeneous and rapidly evolving RNA virus, is the most burdensome pathogen of swine health and wellbeing worldwide. Viral infection induces antigen-specific immunity that ultimately clears the infection. However, the resulting immune memory, induced by virulent or attenuated vaccine viruses, is inconsistently protective against diverse viral strains. The immunological mechanisms by which primary and memory protection are generated and used are not well understood. Here, we summarize current knowledge regarding cellular and humoral components of the adaptive immune response to PRRSV infection that mediate primary and memory immune protection against viruses. View Full-Text

Keywords: PRRSV; T cell; B cell; NK cell; neutralizing antibody; porcine; memory; adaptive immune response PRRSV; T cell; B cell; NK cell; neutralizing antibody; porcine; memory; adaptive immune response





Autor: Michael C. Rahe * and Michael P. Murtaugh

Fuente: http://mdpi.com/



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