CD28: Direct and Critical Receptor for Superantigen ToxinsReportar como inadecuado




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Department of Biochemistry and Molecular Biology, Institute of Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel





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Author to whom correspondence should be addressed.



Abstract Every adaptive immune response requires costimulation through the B7-CD28 axis, with CD28 on T-cells functioning as principal costimulatory receptor. Staphylococcal and streptococcal superantigen toxins hyperstimulate the T-cell-mediated immune response by orders of magnitude, inducing a lethal cytokine storm. We show that to elicit an inflammatory cytokine storm and lethality, superantigens must bind directly to CD28. Blocking access of the superantigen to its CD28 receptor with peptides mimicking the contact domains in either toxin or CD28 suffices to protect mice effectively from lethal shock. Our finding that CD28 is a direct receptor of superantigen toxins broadens the scope of microbial pathogen recognition mechanisms. View Full-Text

Keywords: superantigen toxins; inflammatory cytokine storm; lethal toxic shock; biodefense; CD28 receptor; CD28 dimer interface superantigen toxins; inflammatory cytokine storm; lethal toxic shock; biodefense; CD28 receptor; CD28 dimer interface





Autor: Raymond Kaempfer * , Gila Arad, Revital Levy, Dalia Hillman, Iris Nasie and Ziv Rotfogel

Fuente: http://mdpi.com/



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