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Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Sohngaardsholmsvej 49, Aalborg DK-9000, Denmark





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Abstract Fusarium avenaceum is a widespread pathogen of important crops in the temperate climate zones that can produce many bioactive secondary metabolites, including moniliformin, fusarin C, antibiotic Y, 2-amino-14,16-dimethyloctadecan-3-ol 2-AOD-3-ol, chlamydosporol, aurofusarin and enniatins. Here, we examine the production of these secondary metabolites in response to cultivation on different carbon sources in order to gain insight into the regulation and production of secondary metabolites in F. avenaceum. Seven monosaccharides arabinose, xylose, fructose, sorbose, galactose, mannose, glucose, five disaccharides cellobiose, lactose, maltose, sucrose and trehalose and three polysaccharides dextrin, inulin and xylan were used as substrates. Three F. avenaceum strains were used in the experiments. These were all able to grow and produce aurofusarin on the tested carbon sources. Moniliformin and enniatins were produced on all carbon types, except on lactose, which suggest a common conserved regulation mechanism. Differences in the strains was observed for production of fusarin C, 2-AOD-3-ol, chlamydosporol and antibiotic Y, which suggests that carbon source plays a role in the regulation of their biosynthesis. View Full-Text

Keywords: secondary metabolites; moniliformin; enniatin; carbon; regulation; activation; creA secondary metabolites; moniliformin; enniatin; carbon; regulation; activation; creA





Autor: Jens Laurids Sørensen * and Henriette Giese

Fuente: http://mdpi.com/



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