Treatment with the Hyaluronic Acid Synthesis Inhibitor 4-Methylumbelliferone Suppresses SEB-Induced Lung InflammationReportar como inadecuado




Treatment with the Hyaluronic Acid Synthesis Inhibitor 4-Methylumbelliferone Suppresses SEB-Induced Lung Inflammation - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Division of Basic Medical Sciences, Mercer University School of Medicine, 1550 College St, Macon, GA 31207, USA





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Abstract Exposure to bacterial superantigens, such as staphylococcal enterotoxin B SEB, can lead to the induction of acute lung injury-acute respiratory distress syndrome ALI-ARDS. To date, there are no known effective treatments for SEB-induced inflammation. In the current study we investigated the potential use of the hyaluronic acid synthase inhibitor 4-methylumbelliferone 4-MU on staphylococcal enterotoxin B SEB induced acute lung inflammation. Culturing SEB-activated immune cells with 4-MU led to reduced proliferation, reduced cytokine production as well as an increase in apoptosis when compared to untreated cells. Treatment of mice with 4-MU led to protection from SEB-induced lung injury. Specifically, 4-MU treatment led to a reduction in SEB-induced HA levels, reduction in lung permeability, and reduced pro-inflammatory cytokine production. Taken together, these results suggest that use of 4-MU to target hyaluronic acid production may be an effective treatment for the inflammatory response following exposure to SEB. View Full-Text

Keywords: staphylococcal enterotoxin B; acute lung injury; hyaluronic acid staphylococcal enterotoxin B; acute lung injury; hyaluronic acid





Autor: Robert J. McKallip * , Harriet F. Hagele and Olga N. Uchakina

Fuente: http://mdpi.com/



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