Clostridium perfringens Epsilon Toxin: A Malevolent Molecule for Animals and ManReportar como inadecuado




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1

Biology Department, Wilson College, 1015 Philadelphia Avenue, Chambersburg, PA 17201, USA

2

Veterinary Medical Technology Department, Wilson College, 1015 Philadelphia Avenue, Chambersburg, PA 17201, USA

3

Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Albert-Einstein-Allee 11, Ulm D-89081, Germany

4

Bacteries Anaerobies et Toxines, Institut Pasteur, 28 rue du Docteur Roux, Paris 75724, France





*

Author to whom correspondence should be addressed.



Abstract Clostridium perfringens is a prolific, toxin-producing anaerobe causing multiple diseases in humans and animals. One of these toxins is epsilon, a 33 kDa protein produced by Clostridium perfringens types B and D that induces fatal enteric disease of goats, sheep and cattle. Epsilon toxin Etx belongs to the aerolysin-like toxin family. It contains three distinct domains, is proteolytically-activated and forms oligomeric pores on cell surfaces via a lipid raft-associated proteins. Vaccination controls Etx-induced disease in the field. However, therapeutic measures are currently lacking. This review initially introduces C. perfringens toxins, subsequently focusing upon the Etx and its biochemistry, disease characteristics in various animals that include laboratory models in vitro and in vivo, and finally control mechanisms vaccines and therapeutics. View Full-Text

Keywords: Clostridium perfringens; protein toxin; receptor; animal models; cell culture; vaccines; therapeutics Clostridium perfringens; protein toxin; receptor; animal models; cell culture; vaccines; therapeutics





Autor: Bradley G. Stiles 1,* , Gillian Barth 2, Holger Barth 3 and Michel R. Popoff 4

Fuente: http://mdpi.com/



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