Diastereoselective Desymmetrization of Symmetric Dienes and its Synthetic ApplicationReportar como inadecuado




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Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan





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Abstract The desymmetrization of symmetric compounds is a useful approach to obtain chiral building blocks. Readily available precursors with a prochiral unit could be converted into complex molecules with multiple stereogenic centers in a single step. In this review, recent advances in the desymmetrization of symmetric dienes in the diastereotopic group differentiating reaction and its synthetic application are presented.

Keywords: desymmetrization; symmetric diene; chiral auxiliary; C2-symmetric diol; acetal desymmetrization; symmetric diene; chiral auxiliary; C2-symmetric diol; acetal





Autor: Kenji Nakahara and Hiromichi Fujioka *

Fuente: http://mdpi.com/



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