Amperometric Metronidazole Sensor Based on the Supermolecular Recognition by Metalloporphyrin Incorporated In Carbon Paste ElectrodeReportar como inadecuado




Amperometric Metronidazole Sensor Based on the Supermolecular Recognition by Metalloporphyrin Incorporated In Carbon Paste Electrode - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

State Key Laboratory for Chemo-Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China





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Abstract An amperometric metronidazole MTZ sensor using a glycosylated metalloporphyrin as a recognition element, which was incorporated in a carbon paste electrode, is reported. For the preparation of a MTZ-sensitive active material, 5, 10, 15, 20-tetrakis 2-2, 3, 4, 6-tetraacetyl-β-D-glucopyranosyl-1-O-phenylporphyrin Toglu PPH2 and its MnIII complex MnTo-gluPPCl were synthesized from the reaction of pyrrole with ortho-acetylglycosylated benzaldehyde by Lindsay’s method. The MnToglu PPCl-modified electrode showed excellent selectivity toward MTZ with respect to a number of interferents and exhibited stable response. The calibration graph obtained with the proposed sensor was linear over the range of 2.9×10-3-5.8×10-8 M-L, with a detection limit of 5.8×10-8 M-L for MTZ. Cyclic voltammetric measurements indicated that MnToglu PPCl included in graphite-epoxy resin matrices could efficiently mediate electron transfer from the base electrode to MTZ causing a decrease of reduction potential for MTZ detection. The sensor could be regenerated by simply polishing with an alumina paper, with an excellent reproducibility RSD=1.6%. The experimental conditions such as pH and applied working potential were optimized. The prepared sensor is applied for the determination of MTZ in pharmaceutical preparations and the results agreed with the values obtained by the pharmacopoeia method. View Full-Text

Keywords: Metronidazole; Amperometric sensor; Metalloporphyrin Metronidazole; Amperometric sensor; Metalloporphyrin





Autor: Fu-Chun Gong, Xiao-Bing Zhang, Can-Cheng Guo, Guo-Li Shen and Ru-Qin Yu *

Fuente: http://mdpi.com/



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