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1

Laboratory of Molecular Genetics, National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, Tallinn 12618, Estonia

2

Estonian University of Life Sciences, Kreutzwaldi 5, Tartu 51014, Estonia





*

Author to whom correspondence should be addressed.



Abstract Nanotechnologies have become a significant priority worldwide. Several manufactured nanoparticles - particles with one dimension less than 100 nm - are increasingly used in consumer products. At nanosize range, the properties of materials differ substantially from bulk materials of the same composition, mostly due to the increased specific surface area and reactivity, which may lead to increased bioavailability and toxicity. Thus, for the assessment of sustainability of nanotechnologies, hazards of manufactured nanoparticles have to be studied. Despite all the above mentioned, the data on the potential environmental effects of nanoparticles are rare. This mini-review is summarizing the emerging information on different aspects of ecotoxicological hazard of metal oxide nanoparticles, focusing on TiO2, ZnO and CuO. Various biotests that have been successfully used for evaluation of ecotoxic properties of pollutants to invertebrates, algae and bacteria and now increasingly applied for evaluation of hazard of nanoparticles at different levels of the aquatic food-web are discussed. Knowing the benefits and potential drawbacks of these systems, a suite of tests for evaluation of environmental hazard of nanoparticles is proposed. Special attention is paid to the influence of particle solubility and to recombinant metal-sensing bacteria as powerful tools for quantification of metal bioavailability. Using recombinant metal-specific bacterial biosensors and multitrophic ecotoxicity assays in tandem will create new scientific knowledge on the respective role of ionic species and of particles in toxicity of metal oxide nanoparticles. View Full-Text

Keywords: ZnO; CuO; TiO2; Aquatic toxicity; Bioavailability; Recombinant sensor bacteria; 3Rs; Daphnia magna; Thamnocephalus platyurus; Pseudokirchneriella subcapitata Selenastrum capricornutum; Tetrahymena thermophila; Vibrio fischeri ZnO; CuO; TiO2; Aquatic toxicity; Bioavailability; Recombinant sensor bacteria; 3Rs; Daphnia magna; Thamnocephalus platyurus; Pseudokirchneriella subcapitata Selenastrum capricornutum; Tetrahymena thermophila; Vibrio fischeri





Autor: Anne Kahru 1,* , Henri-Charles Dubourguier 1,2, Irina Blinova 1, Angela Ivask 1 and Kaja Kasemets 1

Fuente: http://mdpi.com/



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