Development of Membrane Selective Electrode for Determination of the Antipsychotic Sulpiride in Pharmaceuticals and UrineReport as inadecuate




Development of Membrane Selective Electrode for Determination of the Antipsychotic Sulpiride in Pharmaceuticals and Urine - Download this document for free, or read online. Document in PDF available to download.

Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071-Murcia, Spain





*

Author to whom correspondence should be addressed.



Abstract The construction and electrochemical response characteristics of a polyvinyl chloride PVC membrane selective electrode for the determination of sulpiride SPD are described. The sensing membrane comprised an ion-exchanger formed between the protonated drug and tetraphenylborate TPB- in a plasticized PVC matrix. The influence of membrane composition on the electrode response was studied. The electrode showed a fast, stable and Nernstian response over a sulpiride concentration range 1 × 10-4– 1 × 10-2 M with a mean slope of 58.4 ± 0.9 mV dec-1 of concentration, a mean detection limit of 4.2 × 10-5 ± 1.2 × 10-5 M, a wide working pH range 2 – 8 and a fast response time 15 s. The electrode showed good selectivity towards sulpiride with respect to some inorganic and organic compounds. When the electrode was applied to the determination of sulpiride in pharmaceuticals and human urine, a high percentage of recovery was attained with no need for sample pretreatment procedures because of the lack of interfering matrix effects. View Full-Text

Keywords: ion-selective electrode; sulpiride determination; pharmaceuticals; urine ion-selective electrode; sulpiride determination; pharmaceuticals; urine





Author: Mª Soledad García * , Joaquín A. Ortuño, Mª Isabel Albero and Mustafa Salem Abuherba

Source: http://mdpi.com/



DOWNLOAD PDF




Related documents