Exploiting Surface Plasmon Resonance SPR Technology for the Identification of Fibroblast Growth Factor-2 FGF2 Antagonists Endowed with Antiangiogenic ActivityReportar como inadecuado




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1

Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Brescia, 25123, Italy

2

Chemistry for Technologies Laboratory and Department of Mechanical and Industrial Engineering, School of Engineering, University of Brescia, Brescia, 25123, Italy





*

Author to whom correspondence should be addressed.



Abstract Angiogenesis, the process of new blood vessel formation, is implicated in various physiological-pathological conditions, including embryonic development, inflammation and tumor growth. Fibroblast growth factor-2 FGF2 is a heparin-binding angiogenic growth factor involved in various physiopathological processes, including tumor neovascularization. Accordingly, FGF2 is considered a target for antiangiogenic therapies. Thus, numerous natural-synthetic compounds have been tested for their capacity to bind and sequester FGF2 in the extracellular environment preventing its interaction with cellular receptors. We have exploited surface plasmon resonance SPR technique in search for antiangiogenic FGF2 binders-antagonists. In this review we will summarize our experience in SPR-based angiogenesis research, with the aim to validate SPR as a first line screening for the identification of antiangiogenic compounds. View Full-Text

Keywords: angiogenesis; fibroblast growth factor-2; heparan-sulfate proteoglycans; heparin; interactions; pentraxin 3; peptides; surface plasmon resonance; thrombospondin-1 angiogenesis; fibroblast growth factor-2; heparan-sulfate proteoglycans; heparin; interactions; pentraxin 3; peptides; surface plasmon resonance; thrombospondin-1





Autor: Marco Rusnati 1, Antonella Bugatti 1, Stefania Mitola 1, Daria Leali 1, Paolo Bergese 2, Laura E. Depero 2 and Marco Presta 1,*

Fuente: http://mdpi.com/



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