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Department of Bioscience and Biotechnology, College of Life Science, Sejong University, Seoul, 143-747, Korea





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Abstract Dendritic cells DCs are antigen presenting cells that are characterized by a potent capacity to initiate immune responses. DCs comprise several subsets with distinct phenotypes. After sensing any dangers to the host via their innate immune receptors such as Toll-like receptors, DCs become mature and subsequently present antigens to CD4+ T cells. Since DCs possess the intrinsic capacity to polarize CD4+ helper cells, it is critical to understand the immunological roles of DCs for clinical applications. Here, we review the different DC subsets, their danger-sensing receptors and immunological functions. Furthermore, the cytokine reporter mouse model for studying DC activation is introduced. View Full-Text

Keywords: dendritic cells; toll-like receptors; pathogen-associated molecular patterns; Interleukin 12; cytokine reporter mouse model dendritic cells; toll-like receptors; pathogen-associated molecular patterns; Interleukin 12; cytokine reporter mouse model





Author: Mia Gi, Wooseok Im and Seokmann Hong *

Source: http://mdpi.com/



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