Preparation of a Nanosized As2O3-Mn0.5Zn0.5Fe2O4 Complex and Its Anti-Tumor Effect on Hepatocellular Carcinoma CellsReport as inadecuate




Preparation of a Nanosized As2O3-Mn0.5Zn0.5Fe2O4 Complex and Its Anti-Tumor Effect on Hepatocellular Carcinoma Cells - Download this document for free, or read online. Document in PDF available to download.

1

School of Basic Medical Science, Southeast University, Nanjing 210009, China

2

School of Clinical Medical Science, Southeast University, Nanjing 210009, China





*

Author to whom correspondence should be addressed.



Abstract Manganese-zinc-ferrite nanoparticles Mn0.5Zn0.5Fe2O4, MZF-NPs prepared by an improved co-precipitation method and were characterized by transmission electron microscopy TEM, X-ray diffraction XRD and energy dispersive spectrometry EDS. Then thermodynamic testing of various doses of MZF-NPs was performed in vitro. The cytotoxicity of the Mn0.5Zn0.5Fe2O4 nanoparticles in vitro was tested by the MTT assay. A nanosized As2O3-Mn0.5Zn0.5Fe2O4 complex was made by an impregnation process. The complex’s shape, component, envelop rate and release rate of As2O3 were measured by SEM, EDS and atom fluorescence spectrometry, respectively. The therapeutic effect of nanosized As2O3-Mn0.5Zn0.5Fe2O4 complex combined with magnetic fluid hyperthermia MFH on human hepatocelluar cells were evaluated in vitro by an MTT assay and flow cytometry. The results indicated that Mn0.5Zn0.5Fe2O4 and nanosized As2O3-Mn0.5Zn0.5Fe2O4 complex were both prepared successfully. The Mn0.5Zn0.5Fe2O4 nanoparticles had powerful absorption capabilities in a high-frequency alternating electromagnetic field, and had strong magnetic responsiveness. Moreover, Mn0.5Zn0.5Fe2O4 didn’t show cytotoxicity in vitro. The therapeutic result reveals that the nanosized As2O3-Mn0.5Zn0.5Fe2O4 complex can significantly inhibit the growth of hepatoma carcinoma cells. View Full-Text

Keywords: As2O3-Mn0.5Zn0.5Fe2O4 complex; preparation; anti-tumor; hepatocellular carcinoma cells As2O3-Mn0.5Zn0.5Fe2O4 complex; preparation; anti-tumor; hepatocellular carcinoma cells





Author: Jia Zhang 1,2 and Dongsheng Zhang 1,2,*

Source: http://mdpi.com/



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