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Center for Disease Vector Research and Department of Entomology, University of California-Riverside, Riverside, 92521, CA, USA


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Abstract Nod-like receptors have emerged as an important family of sensors in host defense. These receptors are expressed in macrophages, dendritic cells and monocytes and play an important role in microbial immunity. Some Nod-like receptors form the inflammasome, a protein complex that activates caspase-1 in response to several stimuli. Caspase-1 activation leads to processing and secretion of pro-inflammatory cytokines such as interleukin IL-1β and IL-18. Here, we discuss recent advances in the inflammasome field with an emphasis on host defense. We also compare differential requirements for inflammasome activation in dendritic cells, macrophages and monocytes. View Full-Text

Keywords: inflammasome; nod-like receptors; innate immunity inflammasome; nod-like receptors; innate immunity

Autor: Gang Chen and Joao H.F. Pedra *



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