A Method for Measuring the Volume of Transdermally Extracted Interstitial Fluid by a Three-Electrode Skin Resistance SensorReportar como inadecuado




A Method for Measuring the Volume of Transdermally Extracted Interstitial Fluid by a Three-Electrode Skin Resistance Sensor - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University, Tianjin 300072, China





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Abstract It is difficult to accurately measure the volume of transdermally extracted interstitial fluid ISF, which is important for improving blood glucose prediction accuracy. Skin resistance, which is a good indicator of skin permeability, can be used to determine the volume of extracted ISF. However, it is a challenge to realize in vivo longitudinal skin resistance measurements of microareas. In this study, a three-electrode sensor was presented for measuring single-point skin resistance in vivo, and a method for determining the volume of transdermally extracted ISF using this sensor was proposed. Skin resistance was measured under static and dynamic conditions. The correlation between the skin resistance and the permeation rate of transdermally extracted ISF was proven. The volume of transdermally extracted ISF was determined using skin resistance. Factors affecting the volume prediction accuracy of transdermally extracted ISF were discussed. This method is expected to improve the accuracy of blood glucose prediction, and is of great significance for the clinical application of minimally invasive blood glucose measurement. View Full-Text

Keywords: blood glucose prediction; interstitial fluid; transdermal extraction; skin resistance sensor; volume measurement blood glucose prediction; interstitial fluid; transdermal extraction; skin resistance sensor; volume measurement





Autor: Dachao Li * , Ridong Wang, Haixia Yu, Guoqing Li, Yue Sun, Wenshuai Liang and Kexin Xu

Fuente: http://mdpi.com/



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