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1

Electrical Engineering Division, Department of Engineering, University of Cambridge, 9 JJ Thomson Avenue, Cambridge CB3 0FA, UK

2

Institute of Nano Electronic Engineering INEE, Universiti Malaysia Perlis UniMAP, Lot 106, 108 & 110, Tingkat 1, Block A, Taman Pertiwi Indah, Jalan Kangar-Alor Setar, Seriab 01000 Kangar, Perlis, Malaysia

3

Schlumberger Cambridge Research, High Cross, Madingley Road, Cambridge CB3 0EL, UK

4

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Sipailou 2, Nanjing 210096, China





*

Author to whom correspondence should be addressed.



Academic Editor: Michael G. Weller

Abstract This proof-of-concept study proposes a novel sensing mechanism for selective and label-free detection of 2,4,6-trinitrotoluene TNT. It is realized by surface chemistry functionalization of silica nanoparticles NPs with 3-aminopropyl-triethoxysilane APTES. The primary amine anchored to the surface of the silica nanoparticles SiO2-NH2 acts as a capturing probe for TNT target binding to form Meisenheimer amine–TNT complexes. A colorimetric change of the self-assembled SAM NP samples from the initial green of a SiO2-NH2 nanoparticle film towards red was observed after successful attachment of TNT, which was confirmed as a result of the increased separation between the nanoparticles. The shift in the peak wavelength of the reflected light normal to the film surface and the associated change of the peak width were measured, and a merit function taking into account their combined effect was proposed for the detection of TNT concentrations from 10−12 to 10−4 molar. The selectivity of our sensing approach is confirmed by using TNT-bound nanoparticles incubated in AptamerX, with 2,4-dinitrotoluene DNT and toluene used as control and baseline, respectively. Our results show the repeatable systematic color change with the TNT concentration and the possibility to develop a robust, easy-to-use, and low-cost TNT detection method for performing a sensitive, reliable, and semi-quantitative detection in a wide detection range. View Full-Text

Keywords: explosives; functionalized nanoparticles; colorimetric; label-free; self-assembly film; aptamer explosives; functionalized nanoparticles; colorimetric; label-free; self-assembly film; aptamer





Autor: Noorhayati Idros 1,2, Man Yi Ho 1,3, Mike Pivnenko 1, Malik M. Qasim 1, Hua Xu 4, Zhongze Gu 4 and Daping Chu 1,*

Fuente: http://mdpi.com/



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