Acute Sleep Deprivation Induces a Local Brain Transfer Information Increase in the Frontal Cortex in a Widespread Decrease ContextReportar como inadecuado




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Biomedical Engineering Research Centre, Department of Automatic Control, Universitat Politècnica de Catalunya, Barcelona 08028, Spain

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Barcelona College of Industrial Engineering, Universitat Politècnica de Catalunya, Barcelona 08037, Spain

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CIBER de Bioingeniería, Biomateriales y Nanomedicina CIBER-BBN, Zaragoza 50018, Spain

4

Drug Research Centre, Hospital de la Santa Creu i Sant Pau, Barcelona 08026, Spain

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Department of Pharmacology and Therapeutics, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain

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CIBER de Salud Mental CIBERSAM, Madrid 28029, Spain

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Sleep Unit, Respiratory Department, Hospital de la Santa Creu i Sant Pau, Barcelona 08028, Spain





*

Author to whom correspondence should be addressed.



Academic Editors: Steffen Leonhardt and Daniel Teichmann

Abstract Sleep deprivation SD has adverse effects on mental and physical health, affecting the cognitive abilities and emotional states. Specifically, cognitive functions and alertness are known to decrease after SD. The aim of this work was to identify the directional information transfer after SD on scalp EEG signals using transfer entropy TE. Using a robust methodology based on EEG recordings of 18 volunteers deprived from sleep for 36 h, TE and spectral analysis were performed to characterize EEG data acquired every 2 h. Correlation between connectivity measures and subjective somnolence was assessed. In general, TE showed medium- and long-range significant decreases originated at the occipital areas and directed towards different regions, which could be interpreted as the transfer of predictive information from parieto-occipital activity to the rest of the head. Simultaneously, short-range increases were obtained for the frontal areas, following a consistent and robust time course with significant maps after 20 h of sleep deprivation. Changes during sleep deprivation in brain network were measured effectively by TE, which showed increased local connectivity and diminished global integration. TE is an objective measure that could be used as a potential measure of sleep pressure and somnolence with the additional property of directed relationships. View Full-Text

Keywords: prolonged wakefulness; sleep deprivation SD; electroencephalography EEG transfer entropy TE prolonged wakefulness; sleep deprivation SD; electroencephalography EEG transfer entropy TE





Autor: Joan F. Alonso 1,2,3,* , Sergio Romero 1,3, Miguel A. Mañanas 1,2,3, Marta Alcalá 1,2, Rosa M. Antonijoan 4,5,6 and Sandra Giménez 4,5,6,7

Fuente: http://mdpi.com/



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