Antiarrhythmic Activities of Some Newly Synthesized Tricyclic and Tetracyclic Thienopyridine DerivativesReportar como inadecuado




Antiarrhythmic Activities of Some Newly Synthesized Tricyclic and Tetracyclic Thienopyridine Derivatives - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Applied Organic Chemistry Department, National Research Centre, Dokki, Cairo, Egypt

2

Research Units, Hi-Care Pharmaceutical Co., Cairo, Egypt





*

Author to whom correspondence should be addressed.



Abstract 3,5-Bis4-chlorobenzylidene-1-ethylpiperidin-4-one 1b was condensed with malononitrile or cyanothioacetamide to yield pyranopyridine 2 and thiopyridopyridine 3b, respectively. Treatment of compound 3b with methyl iodide or ethyl chloroacetate in the presence of a base catalyst gave the corresponding compounds 4 and 5. Compound 3b was reacted with 2-chloro-N-arylacetamide derivatives to yield compounds 7a,b, which were reacted with benzoyl chloride or sodium nitrite to give the corresponding tetracyclic compounds 8a,b and 9a,b, respectively. Compound 2 was treated with acetic anhydride or formic acid to yield the corresponding N-acetylpyranopyridine 10 and pyranopyrimidine 11. Treatment of compound 2 with triethyl ortho-formate gave compound 12, which was cyclized with hydrazine hydrate to give N-aminopyrimidine 13. Some of the synthesized compounds showed high antiarrhythmic activities comparable with Procaine amide and Lidocaine as positive controls.

Keywords: Pyridinethione; Thienopyridine; Thienopyrimidine; Thienotriazine; Pyranopyrimidine; Antiarrhythmic agents Pyridinethione; Thienopyridine; Thienopyrimidine; Thienotriazine; Pyranopyrimidine; Antiarrhythmic agents





Autor: Naglaa A. ABDEL-HAFEZ 1,* , Ashraf 1, M. MOHAMED 1, Abd El-Galil E. AMR 1 and Mohamed M. ABDALLA 2

Fuente: http://mdpi.com/



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