In Vitro Glucose Entrapment and Alpha- Glucosidase Inhibition of Mucilaginous Substances from Selected Thai Medicinal PlantsReportar como inadecuado




In Vitro Glucose Entrapment and Alpha- Glucosidase Inhibition of Mucilaginous Substances from Selected Thai Medicinal Plants - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

College of Public Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand

2

Research and Development Institute, Government Pharmaceutical Organization, Bangkok 10400, Thailand

3

Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand





*

Author to whom correspondence should be addressed.



Abstract As a continuous searching for anti-diabetictype II substances, seven mucilage polysaccharides from selected plants were studied as follow: aerial parts of Basella alba Linn., fruits of Hibiscus esculentus Linn., leaves of Litsea glutinosa Lour. C.B. Robinson, seeds of Ocimum canum Sims., seeds of Plantago ovata Forssk., fruits of Scaphium scaphigerum G. Don. and seeds of Trigonella foenum-graecum Linn. The bioactive properties for entrapping glucose, inhibiting enzyme alpha-glucosidase and free radical scavenger were in vitro studied compared to glucomannan. The physical characteristics for water holding capacity and viscosity were determined. The chemical characteristics were assayed for monosaccharide composition using methanolysis, TMSderivatization and gas chromatography. O. canum mucilage superiorly entrapped glucose compared to glucomannan. This activity was relevant to its highly viscous gelation. S. scaphigerum showed another property of alphaglucosidase inhibition. S. scaphigerum mucilage 0.5% inhibited the enzyme activity by 82.6%, compared to 1-Deoxynorjirimycin by 47.6%. Most mucilages, except O. canum and P. ovata, showed DPPH scavenging activity higher than glucomannan. Galacturonic acid was found in 3 from 7 mucilages namely B. alba, P. ovata and S. scaphigerum. Whereas rhamnose was common sugar found in all seven mucilages. Monosaccharide components of these mucilages were compared to the results from the previous reports.

Keywords: Mucilage; Polysaccharide; Anti-diabetic potential; Free radical scavenger; Physicochemical property Mucilage; Polysaccharide; Anti-diabetic potential; Free radical scavenger; Physicochemical property





Autor: Chanida PALANUVEJ 1, Sanya HOKPUTSA 2, Tanasorn TUNSARINGKARN 1 and Nijsiri RUANGRUNGSI 1,3,*

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados